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Tom 23. nr 4
Grudzień 2018

Management of pregnancy in hereditary angioedema (streszczenie)
Marta Sánchez-Jareño, Rosario Cabañas, Teresa Caballero
Hereditary angioedema due to C1-inhibitor deficiency (HAE) is a rare disease. HAE course can be more severe in female patients due to the activation of contact system by endogen oestrogens. Pregnancy can therefore worsen the disease course in some cases and the HAE management during pregnancy is often a challenge because of the limitation in treatment options. Plasma derived C1 inhibitor concentrate is the election drug for the treatment of acute attacks, short term prophylaxis and long term prophylaxis. In this review we will update the potential variations in HAE clinical course and the indications of the currently available treatments during pregnancy, delivery and breastfeeding. Keywords: Hereditary angioedema, pregnancy, delivery, breast-feeding, C1-inhibitor, treatment
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