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Vol 23. no 1
March 2018

Pathogenesis of large vessel vasculitis as an example of innate and adaptive immunity relations – case report and literature review (summary)
Marcin Milchert, Marek Brzosko
Large vessel vasculitis that include giant cell arteritis (GCA) and Takayasu arteritis (TAK), combine autoimmune and autoinflammatory components to a degree that depends on acquired or innate immune response involvement. In GCA, both components may occur together, independently or sequentially. Polymyalgia rheumatica is a part of GCA-disease spectrum mainly associated with innate immune response hyperactivity. It is sometimes considered to be a form of “vasculitis sine vasculitis”. In TAK there are three-phases of the disease traditionally described: from non-specific inflammatory reaction to lymphocytic infiltration of arterial walls leading to their destruction. This article outlines the basics of pathogenesis of large vessel vasculitis, highlighting the links between acquired and innate immunity responsible for the heterogeneous clinical picture of these diseases. It also presents practical clinical implications of understanding pathogenesis.
Keywords: giant cell arteritis, Takayasu arteritis, pathogenesis
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