Trends in etiopathogenesis of primary Sjögren’s syndrome
Agata Sebastian, Piotr Wiland
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease
and can be a serious disease with excess mortality due to severe organ-
specific involvements and the development of B-cell lymphoma.
PSS is characterized by lymphocytic infiltration of exocrine glands, resulting
in glandular dysfunction. Similarly to many other autoimmune
diseases, the inciting factors that precipitate pSS are poorly understood.
Patients with pSS have specific lymphocytic infiltration of salivary
glands. While this infiltration is well characterized, the pathologic
events that precede and cause this inflammatory cell recruitment are
This review summarizes the potential cytokine families involved in the
etiopathogenesis of primary pSS.
Keywords: primary Sjögren syndrome, pathogenesis
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