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Vol 23. no 1
March 2018

Trends in etiopathogenesis of primary Sjögren’s syndrome (summary)
Agata Sebastian, Piotr Wiland
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease and can be a serious disease with excess mortality due to severe organ- specific involvements and the development of B-cell lymphoma. PSS is characterized by lymphocytic infiltration of exocrine glands, resulting in glandular dysfunction. Similarly to many other autoimmune diseases, the inciting factors that precipitate pSS are poorly understood. Patients with pSS have specific lymphocytic infiltration of salivary glands. While this infiltration is well characterized, the pathologic events that precede and cause this inflammatory cell recruitment are unknown. This review summarizes the potential cytokine families involved in the etiopathogenesis of primary pSS.
Keywords: primary Sjögren syndrome, pathogenesis
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