Analysis of concentration allergenspecyfic IgE against non-steroidal anti-inflammatory drugs in own material
Kinga Lis, Zbigniew Bartuzi
Introduction. Nonsteroidal anti-inflammatory drugs (NSAIDs) currently
occupy a leading position in the frequency of drug-induced hypersensitivity
Aim. The present paper analyses referrals for laboratory tests with regard
to determination of NSAIDs-specific IgE as well as the results of
these tests. The abovementioned referrals were sent to the Immunological
and Allergological Laboratory of the Department of Allergology,
Clinical Immunology and Internal Diseases at University Hospital No. 2
in Bydgoszcz between 17.04.2012 and 16.04.2017.
Material and methods. The analysis took into account age and sex of
patients, number of referrals, the type of drugs for which IgE determination
had been ordered, as well as accompanying tests. The obtained
results were analyzed for the presence of specific IgE.
Results. It was observed that the asIgE determined for NSAIDs accounted
for 2.47% of all referrals that had been received by the laboratory.
The orders included asIgE for the following drugs: acetylsalicylic
acid, paracetamol, ibuprofen, ketoprofen and pyralgine. The most
commonly ordered laboratory test was asIgE for aspirin, less often for
ketoprofen, ibuprofen, paracetamol and metamizole. Half of the referrals
for NSAIDs-specific IgE were combined with referrals for asIgE for
other allergens and their mixtures. Only one positive ketoprofen-specific
IgE test result was obtained.
Conclusions. The analysis of test results suggests non-IgE mediated
bases of hypersensitivity symptoms associated with NSAIDs or other
undetermined causes not connected with these drugs.
Keywords: hypersensitivity, allergy, non-steroidal anti-inflammatory
drugs (NSADIs), IgE, referral for laboratory tests